Platelet Lysate
Los Angeles
WHAT IS PLATELET LYSATE?
Platelet lysate is comprised of concentrated growth factors and cytokines derived from platelet cells from blood. It is similar to platelet rich plasma (PRP) except that the platelet cells are lysed and released first so that the growth factors, cytokines, and chemokines are manually obtained and administered instead of letting the platelet cells naturally release these substances in the applied area. Some studies have shown that growth factors IGF-1, PDGF, TGF-β, and BDNF have a higher concentration with platelet lysate. The benefit of this acellular therapy is to decrease the inflammatory reaction as seen with PRP related to platelet cell granulation and release of inflammatory reactors such as histamine and to exclude inflammatory cells such as white blood cells (leukocytes).
| Growth factors | Origins | Physiological effects |
|---|---|---|
| PDGF | Neuronal cells, astrocytes, oligodendrocytes, vascular cells | Induces stem cell proliferation, neuroprotection, promotes cell migration and proliferation |
| TGF-β | β cells, T cells, dendritic cells, macrophages | Promotes cell proliferation and differentiation, assists with tissue repair and fibrosis, and inhibits activation of immune cells |
| VEGF | Endothelial cells, smooth muscle cells, platelets, neutrophils, macrophages | Angiogenesis and vascular repair, tissue repair, neuroprotection |
| IGF-1 | Hepatic stellate cells, osteoblasts, fibroblasts, macrophages | Promotes growth, cell differentiation, and cell proliferation |
| bFGF | Endothelial cells, bone cells | Induction of neovascularization and neurotrophy |
| EGF | Vascular smooth muscle cells, endothelial cells, neutrophils, macrophages | Promotes wound healing and anti-inflammatory effects |
HOW DOES PLATELET LYSATE WORK?
Platelet lysate provides an immediate delivery of a high concentration of growth factors and cytokine proteins that has shown in research studies to promote a signaling mechanism that attracts necessary healing factors and cells to the injured area. These growth factors are also involved in supporting the creation of new blood vessels (angiogenesis) along with assisting the body with quality tissue formation. Platelet lysate also has demonstrated in clinical studies to support the body’s natural regulation and reduction of inflammation.
BENEFITS OF PLATELET LYSATE:
Platelet lysate is a natural, non-surgical, biologic treatment option using your blood’s growth factors and proteins that can provide adjunct support with the body’s ability to repair tissue with healthy tissue fibers. Research has shown that platelet lysate may be associated with modulating inflammation.
WHO IS A CANDIDATE FOR PLATELET LYSATE?
Individuals interested in supporting their body’s natural healing and recovery processes may wish to explore platelet lysate therapy. This therapy may be considered for people when they have already explored other interventions such as rest, activity modification, physical therapy, along with other supportive measures. Platelet lysate may be considered by people looking for a non-surgical approach as part of their musculoskeletal or recovery plan. Candidates may be seeking an alternative to surgery or may already be recovering from surgery. A formal consultation with Dr. Yoon is recommended to review the individual’s history, current condition, imaging, and goals to determine if platelet lysate therapy is appropriate.
WHAT CAN I EXPECT WITH PLATELET LYSATE?
The consultation with Dr. Yoon will consist of a thorough evaluation and discussion. If platelet lysate therapy is pursued, Dr. Yoon’s office will provide pre- and post- treatment handouts. Because each patient and injury is different, expected outcomes and recovery recommendations will be discussed individually. Necessary prescriptions for orthotics and other braces, biomechanics evaluations, physical therapy prescriptions, and other supportive measures will be provided when appropriate. Continuous patient follow-up will occur at specific timepoints to optimize the overall recovery plan.
WHY CHOOSE DR. STEVE YOON FOR PLATELET LYSATE?
Dr. Steve Yoon is a highly regarded biologics expert utilizing platelet lysate therapy in professional sports making him a top choice for patients in Los Angeles and around the country. He has extensive experience utilizing platelet lysate while in his role as Director of Clinical Regenerative Medicine at the Cedars Sinai Kerlan Jobe Institute and as a consultant for many professional sports teams and sports agencies throughout the country. Dr. Yoon has successfully helped patients over two decades while specializing in the use of platelet lysate and other regenerative therapies to enhance recovery and performance. His personalized and tailored approach with patients and helping them with their quality of life has earned him numerous honors including being recognized annually in Los Angeles as a Super Doctor as well as a Top Doctor nationally by Castle Connolly.
RESEARCH ARTICLES
Fonseca L da, Santos GS, Huber SC, Setti TM, Setti T, Lana JF. Human platelet lysate – a potent (and overlooked) orthobiologic. J Clin Orthop Trauma. 2021;21:101534. doi:10.1016/j.jcot.2021.101534.
Valtetsiotis K, Di Martino A, Brunello M, D’Agostino C, Poluzzi R, Ferri R, Mora P, Traina F, Faldini C. Platelet lysate for the treatment of osteoarthritis: a systematic review of preclinical and clinical studies. Musculoskelet Surg. 2024;108(3):275-288. doi:10.1007/s12306-024-00827-z.
Gupta A, Maffulli N. Platelet lysate and osteoarthritis of the knee: a review of current clinical evidence. Pain Ther. 2024;13(6):1377-1386. doi:10.1007/s40122-024-00661-y
Hosseini S, et al. Comparative evaluation of autologous platelet-rich plasma and platelet lysate injection effectiveness in patients with knee osteoarthritis. [Journal]. 2023. (PMID 37351894)