Exosomes Therapy
Los Angeles
WHAT ARE EXOSOMES?
Exosomes are small extracellular vesicles (EVs) that are secreted from many cells throughout the body including mesenchymal stem cells. The messenger RNA, micro-RNA, lipids, and proteins found in exosomes have been shown to stimulate numerous pathways upon cell uptake. The effect that these exosomes have depend on the cell and micro-environment that it originated from, leading to a variety of use cases in medicine. In regenerative medicine, exosomes are being evaluated and used for their involvement with wound and tissue healing and its anti-inflammatory effects.
HOW DO EXOSOMES WORK?
Exosomes can facilitate cell to cell communication by transporting its biologic cargo and producing a paracrine effect. These secretory effects can induce various reactions including those involved with providing anti-inflammation and tissue regeneration. Oftentimes, these exosomes are found in very high concentration in medium’s that are used with cell therapies including blood, bone marrow, and Wharton’s jelly umbilical cord graft.
BENEFITS OF EXOSOMES
Exosomes are a non-surgical treatment option that can naturally provide anti-inflammatory effects long term. It can reduce pain and swelling and can assist with improved function. By reducing inflammation and harmful bioactive molecules, exosomes can improve the body’s natural healing reactions and decrease the degradation of cartilage, ligaments, and tendons thus providing disease-modifying effects and contribute to tissue repair and integrity.
WHO IS A CANDIDATE FOR EXOSOMES?
Ideal candidates for exosome treatments are individuals seeking a non-surgical solution for pain relief and tissue healing. These include people with chronic joint pain, arthritis, chondromalacia (cartilage damage), meniscus tears, labral tears, ligament sprains and tears, and tendinosis and tendon partial tears. Exosomes may be helpful in situations where traditional treatments such as rest, medications, chiropractic care, acupuncture, and physical therapy have not helped. Candidates may be seeking an alternative to surgery. A formal consultation with Dr. Yoon will be needed to determine if this treatment is appropriate.
WHAT CAN I EXPECT WITH EXOSOME TREATMENT?
The consultation with Dr. Yoon will consist of a thorough evaluation and discussion. Dr. Yoon’s office will also provide a pre and post treatment guideline handout if treatment is pursued. Most treatments require abstaining from the use of non-steroidal anti-inflammatory medications (NSAIDs) one week before and two weeks after the procedure to allow the treatments to naturally work. Because many treatment protocols are tailored to the specific needs of the patient, expectations post treatment will be carefully explained beforehand. Necessary prescriptions for orthotics and other braces, biomechanics evaluations, physical therapy prescriptions, specific location and provider referrals, and other needs will be provided. Continuous patient follow-up will occur at specific timepoints to optimize treatment results.
WHY CHOOSE DR. STEVE YOON M.D. FOR EXOSOME TREATMENT?
Dr. Steve Yoon is a highly regarded biologics expert utilizing exosome treatments in professional sports making him a top choice for exosome therapy for patients in Los Angeles and around the country. He has extensive experience utilizing exosomes while in his role as Director of Clinical Regenerative Medicine at the Cedars Sinai Kerlan Jobe Institute and as a treating consultant for the vast majority of professional sports teams and sports agencies throughout the country. Dr. Yoon has successfully treated patients over two decades while specializing in the use of exosomes and other regenerative therapies to enhance recovery and performance. His personalized and tailored approach with patients and helping them with their quality of life has earned him numerous honors including being recognized annually in Los Angeles as a Super Doctor as well as a Top Doctor nationally by Castle Connolly.
RESEARCH ARTICLES
Wang Z, Li Q, Zhang Y, Chen H, Liu S, Yang L. Efficacy and safety of platelet-rich plasma injections for the treatment of knee osteoarthritis: A systematic review and meta-analysis
Arthur Vithran DT, Xie W, Opoku M, Essien AE, He M, Li Y. The Efficacy of Platelet-Rich Plasma Injection Therapy in the Treatment of Patients With Achilles Tendinopathy: A Systematic Review and Meta-Analysis. J Clin Med. 2023;12(3):995. doi:10.3390/jcm12030995
Chen X, Zhang J, Huang J, Liu K, Zhao Y. Comparative efficacy of different doses of platelet-rich plasma in knee osteoarthritis: a meta-analysis. J Orthop Surg Res. 2025;20(1):650. doi:10.1186/s13018-025-05650-1
Mende E, Sun M, Zhang A. A comprehensive summary of the meta-analyses and systematic reviews on platelet-rich plasma in osteoarthritis and musculoskeletal conditions. Mil Med. 2024;189(11-12):e2347-e2359. doi:10.1093/milmed/usae167
Kwong CA, Woodmass JM, Gusnowski EM, Bois AJ, Leblanc J, More KD, Lo IKY. Platelet-Rich Plasma in Patients With Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared With Corticosteroid Injection: A Double-Blind Randomized Controlled Trial. Arthroscopy. 2021;37(2):510-517. doi:10.1016/j.arthro.2020.10.037
Zeng C, Pan X, Li H, Li Y. Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a meta-analysis. Front Med. 2023;10:1204144. doi:10.3389/fmed.2023.1204144